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Public attitudes to a human challenge study with SARS-CoV-2: a mixed-methods study

(10 February 2022)

Caroline Barker, Katharine Collet, Diane Gbesemete, Maria Piggin, Daniella Watson, Philippa Pristerà, Wendy Lawerence, Emma Smith, Michael Bahrami-Hessari, Halle Johnson, Katherine Baker, Ambar Qavi, Carmel McGrath, Christopher Chiu, Robert C. Read, Helen Ward

Background: Human challenge studies involve the deliberate exposure of healthy volunteers to an infectious micro-organism in a highly controlled and monitored way. They are used to understand infectious diseases and have contributed to the development of vaccines. In early 2020, the UK started exploring the feasibility of establishing a human challenge study with SARS-CoV-2. Given the significant public interest and the complexity of the potential risks and benefits, it is vital that public views are considered in the design and approval of any such study and that investigators and ethics boards remain accountable to the public.

External web link - https://wellcomeopenresearch.org/articles/7-49/v1

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Implementing a social network intervention: can the context for its workability be created? A quasiethnographic study

J. Ellis , I. Vassilev, E. James and A. Rogers - October 27, 2020

Background

Policy makers and researchers recognise the challenges of implementing evidence-based interventions into routine practice. The process of implementation is particularly complex in local community environments. In such settings, the dynamic nature of the wider contextual factors needs to be considered in addition to capturing interactions between the type of intervention and the site of implementation throughout the process. This study sought to examine how networks and network formation influence the implementation of a self-management support intervention in a community setting.

External web link - https://implementationsciencecomms.biomedcentral.com/articles/10.1186/s43058-020-00087-5

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Adult diet in England: Where is more support needed to achieve dietary recommendations?

Dianna M. Smith , Christina Vogel, Monique Campbell, Nisreen Alwan, Graham Moon (June 23, 2021)

Background

Small-area estimation models are regularly commissioned by public health bodies to identify areas of greater inequality and target areas for intervention in a range of behaviours and outcomes. Such local modelling has not been completed for diet consumption in England despite diet being an important predictor of health status. The study sets out whether aspects of adult diet can be modelled from previously collected data to define and evaluate area-level interventions to address obesity and ill-health.

 

External web link - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252877