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bd368e62-bd41-4d7a-a7ea-673ea3582964 ADOPTED PROJECT: High Harm Domestic Violence Perpetrator Pilot Evaluation Chief Investigator: Dr Sara Morgan – University of Southampton Project Team Members: Mrs Katerina Porter – University of Southampton, Mrs Fiona Maxwell – University of Southampton, Professor Julie Parkes – University of Southampton Organisations Involved: Hampshire County Council, Hampshire Constabulary, Office of the Police and Crime Commissioner, Hampshire, The Home Office, Hampton Trust Background data Domestic violence & abuse remains a pressing public health concern In the UK, 18% of adults aged 16+ have experienced domestic abuse from an intimate partner 1 In Southampton, domestic abuse accounts for 33% of violent crime Methods Analysis of routinely-collected anonymised quantitative data on all individuals meeting the Operation’s inclusion criteria (n=321) Interviews with key professionals (n=12) 11,751 individuals identified as perpetrators of domestic abuse in 2 policing districts over 14 months 131 individuals included in the Operation Foundation cohort, for allocation to High-Harm Teams, who attempt to engage perpetrators into a specialist behaviour change programme, ADAPT Results Operation Foundation identifies the domestic abuse perpetrators who pose the highest risk of the highest harm to their victims, and most require Police attention 10% of the Operation Foundation cohort were referred to ADAPT 2% of the cohort completed the ADAPT programme over 24 weeks High-Harm Team officers used new working practices to attempt to engage perpetrators and provide support to make healthy behaviour changes Where perpetrators were unwilling or unable to engage with the behaviour change intervention, High-Harm Team officers relentlessly pursued those perpetrators to disrupt their potential to pose a risk to their victims Qualitative data from High-Harm Team officers suggests that the Operation Foundation method had had positive and worthwhile effects regarding reoffending rates and reduction in risk to victims Further research is needed to determine the effectiveness of the Operation Foundation method CONTACT: k.a.porter@soton.ac.uk s.a.morgan@soton.ac.uk REFERENCES: 1. Robinson, A. L. and Clancy, A. (2017). New initiatives to tackle domestic violence using the Priority Perpetrator Identification Tool (PPIT). Cardiff: Cardiff University. 2. Crime Survey for England & Wales, 2022 3. Southampton Data Observatory, 2022 4. ADAPT programme, run by Hampton Trust

09039be4-7f54-4e52-b415-7d6e49acfe67 Predicting nurse staffing requirements -validation and scoping extension study (PREDICT-NURSE validation and extension) Chief Investigator: Paul Meredith, Senior Research Fellow, University of Southampton Team: Christina Saville, Senior Research Fellow, University of Southampton Chiara Dall’Ora, Associate Professor in Health Workforce, University of Southampton Zlatko Zlatev, Senior Enterprise Fellow, University of Southampton Peter Griffiths, Chair in Health Sciences Research, University of Southampton Ian Dickerson, PPI Representative Tom Weeks - E Systems Implementation Manager Tom.Weeks@porthosp.nhs.uk Sue Wierzbicki - Lead Nurse - Workforce Sue.Wierzbicki@porthosp.nhs.uk Partners: Hampshire and Isle of Wight Integrated Care Board, Hampshire Hospitals NHS Foundation Trust, Portsmouth Hospitals University NHS Trust, Salisbury NHS Foundation Trust. Start: 1 October 2024 End: 30 September 2025 Our aim We aim to show that a computer algorithm we have developed which uses information that is already collected about patients can provide good estimates of the number of nurses needed on hospital wards to provide safe care for the patients. Background information It is important to have enough nurses to care for patients on hospital wards. If there are too few nurses, patients may take longer to recover, suffer complications, or die, and the capacity of the hospital to cope with new admissions is reduced. Also staff well-being is affected by high workloads and there is more staff sickness. Many hospitals use the Safer Nursing Care Tool (SNCT) to help them manage staffing levels. This involves surveying all the patients in a ward perhaps three times a day. Assessing each patient in this way is an extra nursing task and in itself adds to the workload. We have developed a computer algorithm using data from one hospital which can provide similar estimates of nursing staff requirements to SNCT but we need to check that these estimates would keep patients safe if they were followed. What we will do We shall use data collected for a previous study as input to the algorithm to produce estimates of nurse staffing requirements for each ward shift using information which could be known at the time. We will compare actual staffing with the algorithm’s estimate to see if there is a deficit or surplus of staff. For each admission we will examine how these deficits and surpluses relate to patient outcomes. We will compare using the algorithm to set a threshold for safe staffing with using the SNCT estimates as a threshold. Our comparisons will include looking at how good the methods are for wards with higher numbers of under-served groups such as the over 75s, those with learning disabilities and those with mental health conditions. We will measure the effect of staff shortfalls on the number of staff sickness absences. The performance of the algorithm will be checked using data from a second hospital in the database. We shall work with our partners to find out what tools are used to determine nurse and other staffing requirements on a day-to-day basis in community and mental health settings and what data on care requirements and outcomes is electronically recorded. We will discuss with partners what opportunities, potential benefits and practical considerations there are to implementing a predictive tool of staffing requirements. Communicating results We will write an academic paper, produce an article for the Nursing Times, create a poster for display at conferences, and publicise the results on social media. Involving the public We will involve local PPIE group members in evaluating and commenting on the possible uses of a predictive tool to support decisions in the day-to-day management of nurse staffing levels on wards.

80c8b1b5-2419-49ee-b01f-71cd4ac37e9f ARC Wessex programme of research on Medicines Optimisation (MODIFY SPiDeR STOP-DEM) For further information please see the links below MODIFY : The development and iMplementation Of a multidisciplinary medication review and Deprescribing Intervention among Frail older people in primarY care SPiDeR Social Prescribers In Deprescribing Role STOP-DEM : Development of a structured deprescribing intervention for people with dementia or mild cognitive impairment in primary care

93e2e1bd-cd98-479a-93a0-a105e734b0c3 ADOPTED: Exploratory research to examine the health impact of scams and fraud and the current knowledge and systems in the police and partner agencies for targeting and delivering victim support services Lead research ers: Ms Ruth Halkon and Dr Michael Skidmore, The Police Foundation; Professor Mark Button, Director of the Centre for Cybercrime and Economic Crime, University of Portsmouth; Dr Amy Meenaghan, School of Criminology and Criminal Justice, University of Portsmouth. Aims We aim to help the police find those who are most likely to suffer the worst damage to their mental and physical health from falling victim to fraud and make sure they receive the support they need to prevent that damage happening. Background Fraud is the most common and fastest growing crime in England and Wales. Many people do not report fraud and those who do often don’t receive help to reduce the crime's impact on their wellbeing. People affected by fraud can suffer serious physical and mental health problems which can lead to poor physical health, anxiety, depression and suicide. Many factors can shape how victims are affected: stress caused by losing what to them are big sums of money feeling betrayed by someone they thought was their friend or partner blaming themselves feeling friends, family and service providers do not understand them struggling to recover due to existing social or health needs. The police know less about the needs of fraud victims than victims of other crimes like domestic abuse. They are under pressure to improve the service they offer but there are many gaps: Fraud is common crime and can affect victims in many ways, which hinders finding victims who need the most support Those police think are most likely to be harmed, known as ‘vulnerable’, may not suffer the worst effects It is not clear what being 'vulnerable' in a crime context actually means Current systems to address 'vulnerability' mainly focus on cutting crime rather than victim health Research by Which? suggests the impact of fraud on victims' wellbeing amounts to £9.3bn, but we need more data Design and methods Our research will focus on two police forces who work jointly to provide support to victims which is widely seen as the best in the country. The project will focus on their systems, data and services to measure their success and produce a case study for understanding and addressing fraud's health impacts. This will be done via: Reading research papers to find out more about fraud victim impact, vulnerability and victim needs Looking at police and health and welfare data to learn about health impacts of different fraud types Talking to those working for the police, social services, victim support services and key health services Interviews with national subject matter experts Interviews with fraud victims who have been given support after fraud impacted their health to learn how this helped them Patient and public involvement Our overall aim is to involve fraud victims in finding a support framework that works for them Dissemination The report will be launched at an event and published on the Police Foundation website. It will be promoted on our blog, newsletter and social media channels. This fact finding project is a first step to creating a new framework that will be used to find those who need the most help to stop their mental and physical health being badly hit and make sure they are given it. The future project would involve: Organising roundtable events with people Bringing police, health and welfare services together to trial the framework Sharing findings and learning points across the country

74e67d37-7f00-423e-b571-0f47e11e3dca ADOPTED: Investigating the impact of food vouchers on diet composition and the prevention of childhood obesity Principal Investigator: Grace Grove Start Date: 10 May 2021 End Date: 9 May 2023 Background: Childhood obesity is increasing in the UK, and children from disadvantaged backgrounds are more likely to live with obesity. Obesity in childhood is linked to obesity in adulthood and poor health outcomes. It is therefore vital that we work to prevent and reduce inequalities in childhood obesity. We know that children from disadvantaged backgrounds are more likely to have poor diets, and children who have poor diets are more likely to be obese. Therefore, improving diet quality of young families may contribute to preventing the development of childhood obesity. Healthy Start is a scheme in England that aims to improve diet quality by providing vouchers to spend on milk, fruit and vegetables to disadvantaged families. However, the voucher value is modest and has not changed for a decade, despite increasing food prices. The scheme needs assessing to consider how it can best support families, as uptake among eligible families is very low, at 54% nationally. Health visitors support young families, and give extra support to those with increased needs, including those from deprived groups. This provides a unique opportunity to support young families who are at risk of childhood obesity and eligible for Healthy Start. The aim of this research is to understand if voucher schemes can have a positive effect on diet quality of disadvantaged families. This research will contain several elements, including reviewing the literature for evidence on the effectiveness of voucher schemes, speaking to families and health visitors, collecting diet and shopping information from families, and modelling the best approach to a modified Healthy Start scheme. Publications Systematic review of fruit and vegetable voucher interventions for pregnant women and families with young children | Public Health Nutrition | Cambridge Core

df3a87da-ba5f-40cd-8109-9f23cf0662d9 Promoting person-centred care using the CHAT&PLAN conversation guide https://vimeo.com/469226317 Promoting person-centred care using the CHAT&PLANTMconversation guide Project leads: Professor Jackie Bridges (Professor of Older People's Care, School of Health Sciences, University of Southampton), Dr Teresa Corbett (Lecturer, Solent University) Team members: Professor Jackie Bridges (Professor of Older People's Care, School of Health Sciences, University of Southampton), Dr Teresa Corbett (Lecturer, Solent University), Professor Alison Richardson (School of Health Sciences, University of Southampton), Dr Jane Winter (Macmillan Consultant Colorectal Nurse, University Hospital Southampton NHS Foundation Trust), Start: 1 October 2019 Ends: 30 April 2022 Project Partners: University Hospital Southampton NHS Foundation Trust, Southern Health NHS Foundation Trust, Bournemouth University, Macmillan Cancer Support Lay summary The aim of this Wessex ARC project is to share a conversation guide we have developed through our research. The guide helps health and social care staff talk to older adults who have lots of different conditions. The guide has 8 steps that should be followed in a meeting with people about their needs and personal goals. We call the guide “CHAT&PLAN” and we’d like to make sure that people working in health and social care know about it and use it in their work. This website leads to resources to support people to use CHAT&PLAN in their work. We have a new project underway with the Wessex Cancer Alliance that tests out some new ways of supporting people with cancer, including the CHAT&PLAN. Corbett, T., Cummings, A., Lee, K., Calman, L., Fenerty, V., Farrington, N., Lewis, L., Young, A., Boddington, H., Wiseman, T., Richardson, A., Foster, C., Bridges, J. (2020). Planning and optimising CHAT&PLAN: a conversation-based intervention to promote person-centred care for older people living with multimorbidity. PLOS One . https://doi.org/10.1371/journal.pone.0240516 The following people were involved in the research behind the CHAT&PLAN: Dr Hilary Boddington, Professor Jackie Bridges, Dr Lynn Calman, Dr Teresa Corbett, Dr Amanda Cummings, Dr Naomi Farrington, Vicky Fenerty, Professor Claire Foster, Dr Kellyn Lee, Lucy Lewis, Professor Alison Richardson, Dr Jane Winter, Professor Theresa Wiseman, Alexandra Young

6b068013-6ee6-484b-88bf-12a053cec877 Wessex SNSDE Study (SETT Centre) Project lead: Professor Chris Kipps, University Hospital Southampton NHS Foundation Trust Development and Testing of Collaborative Data Science Approaches with the Southampton Emerging Therapies and Technologies Centre and the Wessex Secure Data Environment The Southampton Emerging Therapies and Technologies (SETT) Centre, in partnership with NIHR ARC Wessex, has awarded support to four early-stage data science projects. This is a collaborative initiative to develop and test data science approaches addressing compound pressures across health and care systems. The project aims to build analytic capacity by bringing together clinical, academic, and data science expertise from University Hospital Southampton (UHS), the University of Southampton, and other regional partners with a focus on 4 use cases. Central to this work is the Wessex Secure Data Environment (SDE), part of a national programme to provide safe, secure access to clinical data. The SETT data team curates and onboards health data into the SDE, enabling secure and effective data analysis. Substance Use Disorder: Analysing electronic health records to understand how substance use impacts hospital services and to inform more effective interventions. Neurocritical Blood Pressure Control: Comparing the effectiveness of two drugs (labetalol and nicardipine) in managing blood pressure in very unwell patients, with a focus on clinical outcomes and resource efficiency. Liver Monitoring in IBD: Assessing liver function test monitoring in patients with inflammatory bowel disease (IBD) to improve early detection of liver disease and clinical pathways. Digital Tools for Rare Liver Disease: Evaluating how digital tools can improve care and screening for primary sclerosing cholangitis (PSC), a rare and progressive liver disease. This initiative has a focus on improvements in patient care and resource efficiency, while also building data science capacity to enable innovation in health and care delivery.

Nestor Serrano-Fuentes RN, PhD student and Research assistant for the Long-Term Conditions Research Group, Health Sciences, University of Southampton < Back Traveling back in time: exploring the Netley Red Cross Hospital during World War I Nestor Serrano-Fuentes Nestor Serrano-Fuentes RN, PhD student and Research assistant for the Long-Term Conditions Research Group, Health Sciences, University of Southampton November is remembered as the month in which the First World War ended; a time to remember our loved ones who fell in battle. Between 1914 and 1918, many stories unfolded: stories of life, death, love, births, feelings and emotions. Those feelings flourish today when walking through the green park and woodland at Netley on the Southampton shoreline. I look at the sea, that little orange chapel in the middle of the great esplanade, I close my eyes and visualise the protagonists of this story, talking among themselves, laughing, shouting, touching and hugging… My name is Nestor, I am a young man, nurse and researcher at the University of Southampton. Two years ago, while running on a cold winter morning along the south coast at Netley, something drew my attention. What was a lonely chapel doing here? I stopped to read some information panels and discovered that, in that place had been the Netley Hospital or Royal Victoria Hospital. According to some books, this was the largest British military hospital of all time. Furthermore, with the arrival of the war-wounded its capacity grew yet further Leading to the building of the British Red Cross Hospital just behind the main building and the recruitment of volunteers in the UK and overseas. Netley Hospital in 1918 Sister Harvey and some of the patients from 41 Hut A Japanese nurse who worked at Netley in 1918 - unnamed I needed more information and began to browse the historical archives online. Later I came across a treasure; The Netley British Red Cross Magazine . It was December and I was combing the historical archives in Winchester and there in my hands were prints of those magazines from 1918. They were filled with poems written by soldiers and nurses, cartoons, real photos and countless stories told in the first person. A few days later, I phoned my friend Elena Andina, lecturer of nursing at the University of Leon (Spain). She is a dreamer, humanist, and a person with whom I share a passion for the history of the nursing profession. I said: “You’re not going to believe what I have found! We’ve got some work to do!” We decided to read those six issues of the magazine. We were filled with great affection for the people and stories. We set about starting to analyse and contextualise the data and information, and began to write an article on the history of nursing telling the story of how care was delivered to soldiers during World War I. We were so lucky, it was like travelling in a time machine, an incomparable feeling. After a first analysis, we realised that there was a relationship between what was happening at Netley and the revolutionary thinking and ideas of Florence Nightingale, who is considered the creator of modern nursing. The focus on the environment on care - sunlight, humidity, fresh air, silence during a night shift, empathy, the smallest details that nurses took care of, such as the size of pyjamas for their patients, the use of small boats as a source of leisure for patients and nurses, are just some of the aspects that we glimpsed between those pages. Throughout history, wars and pandemics have shaped and changed the way nursing care has been delivered. If we look back, many of the measures that were applied we continue to use today. During this covid19 pandemic, the importance of open spaces and physical spaces between people, fresh air or sunlight are the same – echoes of the voices speaking from the pages of the Netley magazines in 1918. They say history tends to repeat itself, for better or for worse. What can we learn from it? Let us continue to lovingly preserve it and keep it in mind to acknowledge our ancestors and as inspiration in the search for current and future answers. Nestor Exploring The Netley British Red Cross Magazine: An example of the development of nursing and patient care during the First World War - Nestor Serrano-Fuentes& Elena Andina-Diaz (download below) serranoandina_2020_netley-hospital .pdf Download PDF • 768KB Elena Andina-Diaz - co-researcher Previous Next

eb290c7e-cd77-4244-9d45-322994af9f69 ADOPTED PROJECT: Comparing pharmacological and non-pharmacological interventions for adults with Attention-Deficit/Hyperactivity Disorder (ADHD): systematic review and network meta-analysis Chief Investigator: Professor Samuele Cortese – University of Southampton Project Team Members: Professor Andrea Cipriani – University of Oxford, Associate Professor Corentin Gosling – University of Paris Nanterre, France, Dr Luis Faraht – University of São Paulo, Brazil / Yale University Child Study Center, USA, Dr Cinzia Del Giovane – University of Modena and Reggio, Italy Project partners: Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Oxford Precision Psychiatry Lab, National Institute for Health and Care Research Oxford Health Biomedical Research Centre, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Warneford Hospital, Oxford, UK. Electronic address: edoardo.ostinelli@psych.ox.ac.uk . Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Oxford Precision Psychiatry Lab, National Institute for Health and Care Research Oxford Health Biomedical Research Centre, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Warneford Hospital, Oxford, UK. Department of Psychiatry, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Oxford Precision Psychiatry Lab, National Institute for Health and Care Research Oxford Health Biomedical Research Centre, Oxford, UK. Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy; Institute of Primary Health Care, University of Bern, Bern, Switzerland. Hampshire and Isle of Wight NHS Foundation Trust, Southampton, UK; Department of Psychiatry, Faculty of Medicine, University of Southampton, Southampton, UK. Psychology Services, London, UK; Department of Psychology, Reykjavik University, Reykjavik, Iceland. Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Warneford Hospital, Oxford, UK. The National Attention Deficit Disorder Information and Support Services, Edgware, UK. Hampshire and Isle of Wight NHS Foundation Trust, Southampton, UK Full team listing including PPI :O stinelli EG, Schulze M, Zangani C, Farhat LC, Tomlinson A, Del Giovane C, Chamberlain SR, Philipsen A, Young S, Cowen PJ, Bilbow A (PPI), Cipriani A, Cortese S Ended: 28th February 2024 Background: It is currently unclear how different treatment options for preschool children with ADHD compare with each other in terms of efficacy and safety. We will use data from available randomised controlled trials (RCTs) and apply an advanced and innovative statistical approach (network meta-analysis) to answer this question. What did we find out? We found that Stimulant medications and atomoxetine are the only treatments that clearly help reduce the main symptoms of ADHD in the short term, based on both what patients say and what doctors observe. However, people were less likely to stick with atomoxetine than with a placebo (a dummy pill). There was no evidence available other important things like improving quality of life, and we don’t know much about how well they work in the long run. Non-medication treatments had mixed results depending on who was doing the rating. This study gives the most complete picture so far of how different treatments for adult ADHD compare to each other. It can help guide treatment choices, but those choices should always be based on a careful look at both the benefits and risks — and on what matters most to the individual. The study is already informing clinical guidelines, e.g., the ongoing guidelines from APOSARD (USA). The study has informed a freely available platform ( https://ebiadhd-database.org/ ) that has been utilised by 15,000 colleagues around the world and improved through feedback from 1,000 stakeholders worldwide See medication and treatment ratings Next Steps To test the impact of the platform on knowledge and clinical practice To contact guideline bodies in the UK (eg NICE) and abroad to bring the network meta-analysis and the related platform to their attention. Publications Comparative efficacy and acceptability of pharmacological, psychological, and neurostimulatory interventions for ADHD in adults: a systematic review and component network meta-analysis - ScienceDirect

2bde6957-3a7b-4fc1-81e9-51f920491c2f Developing a core cohort of community researchers in Wessex: towards a sustainable Wessex Community of Practice for public health research co-production Chief Investigator: Professor Nisreen A Alwan, Professor of Public Health, Centre for Population Health Sciences, School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton and University Hospital Southampton NHS Foundation Trust Team: Dr Donna Clutterbuck, Research Fellow, University of Southampton Megan Barlow-Pay, PPIE Lead, NIHR Research Support Service Professor Julie Parkes, Professor of Public Health, University of Southampton, University Hospital Southampton NHS Foundation Trust and Health Education England Wessex Dr Kath Woods-Townsend, Associate Professor (Research) and Lifelab Project Manager, University of Southampton Mirembe Woodrow, Senior Public Health Practitioner, Southampton City Council and PhD student, University of Southampton Partners: Hampshire and Isle of Wight NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, Bournemouth University, University of Portsmouth, University of Southampton, Southampton City Council, NIHR Research Support Service Specialist Centre for Public Health, LifeLab, University of Southampton / NIHR Southampton Biomedical Research Centre, Health Determinants Research Collaboration, Southampton, Southampton Centre for Research Engagement & Impact (SCREI), Centre for Seldom Heard Voices, Bournemouth University, HDRC Portsmouth Start: 1 October 2024 End: 31 March 2026 Summary Public health research priorities must stem from the needs of the communities served by such research, particularly those most socially and economically disadvantaged, as well as community groups that are seldom heard. Therefore, community members with lived experience of health conditions and the various factors shaping health and wellbeing have a central role in shaping such research. Co-creating research with the public can lead to research findings that are more relevant to population health and wellbeing, leading to a reduction in heath inequalities. The purpose of this project is to develop a core ‘cohort’ of community public health researchers using an approach that considers the multiple social forces that shape people’s identities to inform research design that is meaningful to Wessex local communities. This cohort will form a Community of Practice (CoP) for research co-design that can help us reach those seldom heard groups in our local communities and understand underrepresented perspectives to inform relevant and meaningful health research priorities, questions and methods. People from such communities are more likely to feel comfortable to inform research that is led or co-led with community researchers. This project will be a Partnership between the NIHR Research Support Service (RSS) National Specialist Centre for Public Health (NSCPH) which aims to support the generation of high-quality research evidence aimed to inform decisions about which interventions have the greatest likelihood to improve population health and reduce health inequalities, and the Healthy Communities Theme of the NIHR ARC Wessex. In the first stage of the project, we will engage with stakeholders, including members of the public, voluntary organisations, Local Councils and health services to shape the project protocol and to co-develop its strategy, key milestones and outcomes. In the second phase of the project, we envisage a group of community researchers being recruited and trained in participatory research (or other research methods of their choice) and be provided with opportunities to link in with health researchers. In the third phase of the project, the community researchers will then choose a pathway (or more) that suits their needs from conducting community-based research, linking with other community members to inform further research projects, co-creating research ideas, or informing research proposals developed by researchers within the ARC or through the RSS. In the fourth phase of the project, we will evaluate the above activities and synthesise and disseminate lessons learnt from the project towards sustainability of our CoP framework. The project’s Research Fellows will also work with public contributors to disseminate findings in ways that are meaningful, alongside preparing publication materials for journals and conferences, and producing infographics. The CoP will help us to co-design health research based on local and regional need; provide stakeholder input into public health research proposals in Wessex; contribute to governance and delivery of NSCPH; and support meaningful and equitable research partnerships with community stakeholders and the public.

Impact Since ARC Wessex began in October 2019 it focussed on the tackling the health and care challenges of our communities and beyond. In addition to our four research themes, ARC Wessex developed a Mental Health Hub and secured funding to look at the challenges and needs of our social care systems. We also led on the National efforts to increase the number of researchers working on dementia (DEM-COM ) and the Healthy Ageing, Dementia and Frailty National Priority Programme with collaborated with the ARC network across England. Here we show examples of the impact of our completed research and the benefits to patients and the wider communities in Wessex. Read ARC at 5 - The story so Far | here Find out how our research has helped people at risk of food insecurity During the Covid-19 outbreak hospital beds were under immense pressure learn about how we created a safe way to care for people at home Many people take multiple medications as they age. Our research has helped safely reduce medications where they aren't needed. Adult social care supports some of the most vulnerable people in society. We helped train social workers to use research to improve services. Around 20% of people in the UK experience domestic abuse in their lifetime. Our research has helped test ways to reduce it. There has been a sharp rise in 999 calls for those at end of life. Our researchers looked at how paramedics are coping with this pressure. People at the end of life, through cancer or other illnesses can be vulnerable to abuse. Researchers created a tool to help spot the signs Around 30,000 people are seriously injured and 1,700 are killed in road traffic collisions in England every year. Research could improve safety Improving physical activity and lives in care homes The ImPACT study looked to create and test the feasibility of using trained exercise volunteers in care home settings to increase the amount of physical activity for older people living there. Are we making the right decisions on nursing numbers? In England a general yardstick is used to work out the number of nursing staff needed to look after patients on a ward in hospital. Recent research has now updated NHS guidance with its findings Online tool for Long Covid support A website to support people living with Long Covid offers a symptom checker, advice on seeking support, and encourages people to talk about their symptoms with professionals, friends and family. Clever help matches care and skills for district nurses The complexity of managing a busy team of district nurses has been made simpler by using computer and mathematical modelling to schedule visits - and the system could go further. Researchers test new ways to help tackle childhood obesity In England, over a fifth of children aged 4–5 years were classed as overweight or obese in 2021/22. A team of ARC Wessex researchers has been testing a way to help families improve kids diets. Helping older people get the right medicine 1 in 3 people aged 65 and older take 5 or more medicines every day. Some of these drugs may no longer be appropriate. We developed tools to help safely reduce medications where needed and review what people want from their medications. Building research capacity in Wessex 100 + 10 + £2M Invested We have trained more than 100 health and care professionals to make their first steps into research ... more than 10 PhD students are making their next move in research ..and growing numbers of Post Doctorate researchers getting to grips with the issues that effect us all

eda5a835-7cd7-4129-9513-a5eae9f5b7ce ADOPTED: An observational longitudinal cohort study to investigate Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer’s disease (CONGA) Principal Investigator: Professor Chris Kipps Team: Steven Chance, Oxford Brain Diagnostics Ltd Robyn Davies, Cardiff and Vale University LHB Gail Hayward, University of Oxford, Nuffield Department of Primary Care Health Sciences, Margaret Glogowska, University of Oxford, Nuffield Department of Primary Care Health Sciences Jane Wolstenholme, University of Oxford, Health Economics Research Centre Filipa Landeiro, University of Oxford, Health Economics Research Centre Angus Prosser, University of Southampton Main Funding: NIHR i4i Starts: 6 March 2022 Ends: 31 June 2025 Summary Dementia is an umbrella term for a group of neurodegenerative diseases that cause cognitive and/or behavioural impairment that affect an individual’s function and daily living. Alzheimer’s disease (AD) is the most common dementia subtype, accounting for 60-70% of cases, followed by vascular dementia, mixed dementia, dementia with Lewy bodies, and frontotemporal dementia. Timely and accurate diagnosis of dementia is essential for appropriate care planning and signposting to sources of support. Early diagnosis and implementation of carer and patient interventions has been shown to improve patient and carer outcomes including health-related quality of life (HR-QoL) and delayed patient institutionalisation. With the promise of new therapeutic targets that may slow the progression of Alzheimer’s disease with early and targeted intervention, accurate and timely diagnosis is critical. Diagnosis is however challenging. Difficult cases can leave patients with uncertain diagnoses for long periods of time, where a “wait and see” approach is often employed when diagnostic tests are inconclusive. This can cause significant stress to both individuals living with cognitive impairment or dementia and their families. Definite dementia subtype diagnosis can currently only be obtained through post-mortem histopathological confirmation. Participants will be recruited through secondary and tertiary centres where diagnostic investigation or patient monitoring is underway. Participants will be followed for two years at 6 monthly intervals to determine change on standard cognitive and functional measures and collection of participant and companion reported health and social care events, with MRI examination at baseline and 24 months.