Long Term Conditions publications

Nurses delivering person-centred multiple long-term condition reviews in primary care: a secondary analysis of qualitative data

Lippiett KA, Turner A, Coope C, Mann C, Moult A, Baker D, Chilcott S, Jinks C, Dziedzic K, Finney A, Salisbury C, Johnson R, Portillo-Vega MC

General practice nurses in England often manage long-term conditions, with more  people now living with multiple conditions (MLTC). Evidence on the effectiveness  and delivery of person-centred care for MLTC is limited, and the nurse’s role —  including necessary training — remains underexplored. 

The aim of this study was to identify and characterise general practice nurses’ experiences of undertaking  person-centred multiple long-term condition reviews in England.

https://doi.org/10.3399/bjgpo.2025.0184

Engaging Patients with Heart Failure in Diet and Nutritional Health Behaviors Through mHealth Applications - A Restricted, Systematic Review

Andrikopoulou E, Austin RC, Ahmad F, Husebø AML

The aim of this study was to examine recent mHealth interventions aimed at supporting diet and nutrition behaviours in heart failure (HF). The review included studies of mobile applications (apps) that incorporated at least one diet- or nutrition-related component published in the last 5 years, in English and targeted for a heart failure population. The review summarises diet and nutrition features and evaluation, engagement strategies within these apps, and reporting of how strategies relate to changes in nutrition-focused health behaviours in people with HF. The review was restricted by period (years) of articles retrieved, percentage of duplication in researchers checking the inclusion and data extraction, and number of databases searched.

https://doi.org/10.1007/s11897-025-00739-4

February 2026

Calzada García M, Ayala A, Navarta Sánchez MV, Palmar Santos AM, Portillo MC, González García B, Carabajal Pendón E, López Manzanares L, Pedraz Marcos A.

Impact of a community-based multisectoral intervention on the health of individuals with parkinson's disease and their family caregivers

The objective of this study was to evaluate the impact of a community-based multisectoral intervention aimed at optimizing the use of local resources on the quality of life (QoL), perceived social support, and health status of individuals with Parkinson's disease (PD) and their family caregivers.

https://doi.org/10.1016/j.semerg.2026.102694

February 2026

Engaging Patients with Heart Failure in Diet and Nutritional Health Behaviors Through mHealth Applications - A Restricted, Systematic Review

Andrikopoulou E, Austin RC, Ahmad F, Husebø AML

The purpose of this review was to examine recent mHealth interventions aimed at supporting diet and nutrition behaviours in heart failure (HF). 

The review included studies of mobile applications (apps) that incorporated at least one diet- or nutrition-related component published in the last 5 years, in English and targeted for a heart failure population. The review summarises diet and nutrition features and evaluation, engagement strategies within these apps, and reporting of how strategies relate to changes in nutrition-focused health behaviours in people with HF. The review was restricted by period (years) of articles retrieved, percentage of duplication in researchers checking the inclusion and data extraction, and number of databases searched.

https://doi.org/10.1007/s11897-025-00739-4

February 2026

Co-Design of a New Integrated Care Model With People Affected by Huntington's Disease: A Mixed Methods Study

Pires SB, Kunkel D, Manera K, Goodwin N, Kipps C, Portillo MC

People living with neurological conditions have needs that require an integrated care approach. Existing models of integrated care have often emphasized system structures but neglected the micro-level interactions that matter most to people.

The objective of this project was to develop a micro-level model for integrated care that represents the care components most valued by people affected by Huntington's disease (HD).

https://doi.org/10.1111/hex.70584

February 2025

Ignoring and conflating sex and gender in cardiovascular research limits the application of evidence-based interventions

Wierenga   KL, Austin RC

Until early in the 1900’s interventional research participation was mainly limited to men. Currently there continues to be a sex and gender mismatch between populations and research. Which includes historical and landmark cardiovascular studies limited to men, the absence of sex-disaggregated data, and limited use of biological variables. Research shortfalls continue despite evidence that both sex and gender impact outcomes.

Sex and gender are important consideration to health and decision making. It is critical that we advance cardiovascular science with studies and interventions that consider both to decrease health inequalities. There are broad differences in biologic, roles, identities, and behaviours that are influenced by sex and gender. To create optimal interventions for a diverse population there is a pressing need to identify diverse needs, use research methodology as defined by SAGAR, and careful design of interventions responsive to these findings.

https://doi.org/10.1093/eurjcn/zvaf221

January 2026

A mixed-methods study to explore the modifiable aspects of treatment burden in Parkinson’s disease and develop recommendations for improvement

Tan QY, Ibrahim K, Roberts HC, Amar K, Fraser SDS

People with Parkinson's (PwP) and their caregivers have to manage multiple daily healthcare tasks (treatment burden). This can be challenging and may lead to poor health outcomes.

The objective of this study was to assess the extent of treatment burden in Parkinson's disease(PD), identify key modifiable factors, and develop recommendations to improve treatment burden.

https://doi.org/10.1371/journal.pone.0338620

December 2025

eHealth interventions to support colorectal cancer patients' self-management after discharge from surgery-an integrative literature review

Husebø ALM, Søreide JA, Kørner H, Storm M, Wathne HB, Richardson A, Morken IM, Urstad KH, Nordfonn OK, Karlsen B

Colorectal cancer (CRC) creates elevated self-management demands and unmet support needs post-discharge. Follow-up care through eHealth post-primary surgery may be an effective means of supporting patients' needs. This integrative review describes the evidence regarding eHealth interventions post-hospital discharge focusing on delivery mode, user-interface and content, patient intervention adherence, impact on patient-reported outcomes and experiences of eHealth.

https://doi.org/10.1007/s00520-023-08191-7

Dcember 2023

A Co-Produced Stakeholder Workshop to Identify Key Time Points and Targets for Life-Course Prevention of Multiple Long-Term Conditions

Stannard S, Wilkinson R, Gill JK, McMahon J, Welch J, Fraser SDS, Alwan NA

The MELD-B project is a multidisciplinary research consortium with one of its aims focused on identifying childhood targets for the prevention of multiple long-term conditions (MLTCs). Drawing upon the expertise of policy and practice stakeholders can inform research questions, data analysis, and contribute to meaningful and practical outputs. In pursuit of this collaborative approach, a stakeholder workshop, co-designed with people with lived experience, was conducted to inform the next steps of the early prevention workstream of the MELD-B project.

https://doi.org/10.1111/hex.70475

December 2025

Understanding the potential role of Social Prescribing Link Workers in supporting identified needs of people with physical and mental long-term conditions: a qualitative study

Linceviciute S, Ambrosio L, Baldwin DS, Portillo MC

The Social Prescribing Link Worker (SPLW) approach is a means for supporting individuals and communities with diverse needs, with its reach and impact widely recognised in health and community systems. However, SPLW support for people with long-term physical and mental health conditions (P + MH LTCs) has been variable and there are knowledge gaps such as unheard voices of those with a varied engagement in SPLW support.

We undertook a study to better understand the potential relevance of SPLW support for addressing the needs of individuals with P + MH LTCs. Its aim was to explore a range of health and psychosocial needs of people living with P + MH LTCs and to examine perspectives on how the SPLW role supports the complex needs of this group.

https://doi.org/10.1186/s12875-025-02990-z

November 2025

Modelling the joint impact of early-life interventions on adult health: an illustrative example of multiple long-term conditions with role limitations in midlife using the 1970 British Cohort Study (BCS70)

Stannard S, Berrington A, Ziauddeen N, Fraser SDS, Paranjothy S, Owen RK, Alwan NA

Evidence on how policy interventions early in childhood can prevent or delay multiple long-term conditions (MLTCs) is limited. We modelled prevention scenarios using five early-life domains on the outcome of MLTCs with role-limitation using effectiveness data of combined real-life early interventions.

https://doi.org/10.1186/s12916-025-04467-3

November 2025

Management of Parkinson's in the Community: Interests and Expectations of People Living with Parkinson's, Family Carers, Healthcare Professionals and Stakeholders in Spain.

Pedraz-Marcos   A, Palmar-Santos AM, Portillo MC, Navarta-Sánchez MV

This study aimed to explore the interests and expectations of people living with Parkinson’s disease (PD), family carers, health and social care professionals, and key stakeholders regarding relevant systems of support and community resources for PD management. As part of the OPTIM-PARK project (Optimisation of Community Resources and Systems of Support to Enhance the Process of Living with PD), an exploratory qualitative study was conducted in Spain. 

Forty-one participants completed a GENIE concentric circles mapping exercise to identify existing support systems and community resources. These maps informed subsequent semi-structured interviews. All interviews were digitally recorded and transcribed verbatim for thematic analysis. Participants identified several barriers to effective collaboration across healthcare and social care systems, including poor understanding of PD, limited financial resources, and insufficient communication among professionals and sectors. Facilitators for improved community-based PD management included personalised care pathways, shared decision-making, improved access to professional services and local resources, and the strategic use of Information and Communication Technologies (ICTs). Participants emphasised the need for long-term investment and strong institutional commitment to reinforce community-based support networks for individuals living with PD.

https://doi.org/10.1177/23333936251384434

November 2025