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Guidance for publications As an NIHR researcher you are required to acknowledge NIHR ARC Wessex and inform ARC Wessex when you have submitted a publication. Notification should be sent to arcwessex@soton.ac.uk . When acknowledging the NIHR, please use the relevant statement below ARC Wessex funded projects This study is funded by the National Institute for Health and Care Research ARC Wessex. The views expressed in this publication are those of the author(s) and not necessarily those of the National Institute for Health and Care Research or the Department of Health and Social Care. ARC Wessex adopted projects This study is supported by the National Institute for Health and Care Research ARC Wessex. The views expressed in this publication are those of the author(s) and not necessarily those of the National Institute for Health and Care Research or the Department of Health and Social Care. Academic Career Development Awards (Name) received(s) support from the NIHR Applied Research Collaboration ARC Wessex and funded through an {insert name of award e.g. NIHR ARC Wessex Internship/PhD fellowship, Post Doctoral Fellowship). The views expressed are those of the authors and not necessarily those of the NIHR, NHS or Department of Health and Social Care. For individuals listed as co-funded ARC investigators and where the research output is linked to the ARC Wessex portfolio please use the following This study is supported by the National Institute for Health and Care Research ARC Wessex. The views expressed in this publication are those of the author(s) and not necessarily those of the National Institute for Health and Care Research or the Department of Health and Social Care. Download the Funded by NIHR logo Download

Alignment with Health and Social Care Priorities Project Outputs Buy-in and Engagement Fit with Health and Social Care Systems Alignment with Health and Social Care Priorities Outcomes and Impact Adoption and Spread Checklist, webinar and resources Quick links: Project Outputs This domain helps you consider how implementation of your project output(s) fit with the changing needs of the health and social care systems and local, regional and national directives and policy. No FAQs yet This category doesn't have any FAQs at the moment. Check back later or explore other categories. What should I consider for my project? Adoption and Spread Project Outputs Buy-in and Engagement Fit with Health and Social Care Systems Alignment with Health and Social Care Priorities Outcomes and Impact Case study Staff Wellbeing (SWP) project “We knew that senior managers were keen to understand the wellbeing needs and priorities of staff, but we did not know how to address this. By consulting with colleagues from a partner organisation, we were able to understand how they approached this. They informed us that they had conducted an anonymous survey with staff to ascertain key needs and priorities for wellbeing. With their guidance we collaborated with a local research and evaluation partner who helped us design the questions for a survey administered within our organisation. In this way we could make sure any initiatives arising from the project were aligned to staff needs. When we conducted the survey, we realised one key factor impacting on staff wellbeing was influenced by a national policy initiative which had resulted in changes to working practices within our organisation. We reflected that we should have reviewed national policies more closely at an early stage, to ensure that our survey questions considered the potential impact of these. We have since adapted the survey to include questions relating to the impact of these policies. The survey findings have provided important insights into how national policies impacted on staff wellbeing at an organisational level as well as reinforcing the importance of wellbeing initiatives being aligned to local, regional and national priorities.” Take away tips Implementation is more likely to be successful when it aligns with the priorities of all relevant stakeholders Understanding how implementation may align at local, regional, and national levels is key

7fc9e212-9328-4765-add4-7315e187c43b Workforce Evaluation Toolkit project (WET) Outline: This is a commissioned piece of work from the ARC Wessex Workforce & Health Systems (WHS) theme to support them with regular requests from healthcare providers. The project is to iteratively develop a generic toolkit for the evaluation of new workforce roles across healthcare. The aim during the current project is to build a first trial version to prove the toolkit concept and generate buy-in from system partners. The Bakker’s Workforce engagement model Burnout forms the conceptual basis for evaluation toolkit. The deliverable for this project is a minimal viable product, in the shape of a workforce evaluation toolkit. Team: Ruth Barker Programme Manager – Insight Health Innovation Wessex . Cheryl Davies, Senior Programme Manager Innovation Adoption, Health Innovation Wessex. Rachel Bailey Senior Programme Manager - Insight, Health Innovation Wessex. Ends: 30 June 2024 More detailed outline or project and partners Workforce Evaluation Project Work Packages 011223[99] .docx Download DOCX • 390KB

Fit with Health and Social Care Systems Project Outputs Buy-in and Engagement Fit with Health and Social Care Systems Alignment with Health and Social Care Priorities Outcomes and Impact Adoption and Spread Checklist, webinar and resources Quick links: Project Outputs This domain helps you consider how implementation of your project output(s) fit with the changing needs of the health and social care systems and local, regional and national directives and policy. No FAQs yet This category doesn't have any FAQs at the moment. Check back later or explore other categories. What should I consider for my project? Adoption and Spread Project Outputs Buy-in and Engagement Fit with Health and Social Care Systems Alignment with Health and Social Care Priorities Outcomes and Impact Case study Parkinson’s disease Charity Community Outreach Project (PCCOP) team "We took time to understand how the aims of our project related to local and national policy and research on improving awareness of Parkinson’s disease in the community. We also spoke to other people within our local networks about their awareness of projects relating to the topic. Because of this, early on we realised there was a project with similar aims being undertaken by another local organisation. Though this was a challenge, as we had taken time to speak to people within our local networks, we had the opportunity to consider whether our project would be able to offer something different. We realised that though the projects had similar aims they were involving different stakeholder groups. We were also able to attend learning events from the other project to understand which steps may be helpful to repeat and avoid in our own project. This was invaluable as it saved both time and resources of those involved. It also ensured that our project fitted with local and national aims and provided something of real benefit and value to our local community.” Take away tips Implementation has a greater chance of success if it fits with the changing needs and priorities of the health and social care systems into which it is being introduced Involvement of stakeholders is key to identifying and understanding fit

7a002421-31aa-4897-bd4d-da37a8b4cf6a Avoiding care escalations through targeted care coordination for people with multiple long-term conditions – a knowledge mobilisation project Chief Investigator: Simon Fraser, Professor of Public Health, University of Southampton Team: Nisreen Alwan, Professor of Public Health, University of Southampton, Lead for the Healthy Communities theme (from 1st Oct 2024), NIHR ARC Wessex. Robin Poole, Consultant in Public Health, Southampton City Council. Michael Boniface, Professorial Fellow of Information Technology, Director of the IT Innovation Centre, University of Southampton, and lead for the Workforce and Health Systems theme, NIHR ARC Wessex. Kelly Cheung, PPI lead, NIHR ARC Wessex and University Hospitals Southampton. Emilia Holland, Public Health Registrar, University of Southampton. Seb Stannard, Research Fellow, MELD-B project, University of Southampton. Claire Sheikh, Senior Pharmacist, Living Well Partnership, Southampton. Kelly Hislop Lennie, Principal Academic in Adult Nursing, Bournemouth University. Lynn Laidlaw, Patient and public contributor and researcher, PPI contributor MELD-B Sally Dace, PPI contributor MELD-B and Wessex ARC James McMahon, PPI contributor MELD-B, School of Primary Care Research UoS, South West Genomic Medicine Service. Lead PPIE for DIALOR, a digital intervention addressing frailty in Bournemouth University Partners: Hampshire and Isle of Wight Integrated Care Board, University Hospital Southampton NHS Foundation Trust, Bournemouth University, Southampton City Council, Living Well Partnership. Start: 1 October 2024 End: 31 March 2026 Summary This project is about taking knowledge that has been learned from two ongoing research studies about living with multiple long-term health conditions to see if we can apply it in a ‘real life’ setting in a large general practice in Southampton. Two research projects called ‘MELD-B’ and ‘the ARC Treatment Burden study’ have identified many aspects that make living with multiple long-term conditions challenging for people. This ‘workload’ might make it more likely that people feel overwhelmed by their health conditions. If people have a high workload, and particularly if they are frail, this can end up with them needing to be admitted to hospital. We have also identified that some aspects of people’s early life can make it more likely that they are admitted to hospital in middle age. If such challenges are recognised in advance and appropriate help provided, such unplanned admissions might be avoided. Care coordinators are people working in NHS settings, including GP surgeries, to identify and support people at risk of such admissions. They have a lot of people on their books and it can be challenging to know who needs what help, and who needs it most urgently. We want to see if the things we have learned from our previous research study can help the care coordinator make these decisions. In this short project we plan to do this in a large practice in Southampton, the Living Well Partnership, which looks after about 45,000 people. We plan to: · collate all the aspects identified in these studies that might make people more vulnerable · make sure we understand the current way care coordinators identify and engage with patients · work with all the relevant people in the practice to make sure we take people on this journey with us · undertake some workshops, co-led by PPI contributors, to co-develop the strategy for adding new aspects (such as the ‘workload’ and early life aspects mentioned above) to current approaches · test the addition of adding these in Living Well Partnership and evaluate the process We will share our findings at an event involving as many of the team from the Living Well Partnership as we can and get their feedback. This event will also include other relevant interested parties, such as those from the Integrated Care Board. PPI contributors have been deeply involved in the work of MELD-B, have helped to shape this proposal and will continue as co-investigators. They will be reimbursed for their contributions according to NIHR guidance. Read the public policy briefing

663cd08e-9825-45c9-8e1b-c94d485206ee COMPLETED SOCIAL CARE: Building capacity in social care through co-produced research and a research learning partnership between University of Portsmouth and Portsmouth City Council Background Social care is facing many challenges and, in a time where staff are stretched and resources are low, research can feel like a luxury rather than part of daily activities. Yet research is crucial for improving practice and finding innovative ways to overcome challenges. To increase capacity in social care research, academia and social care need to work together to understand each other and co-produce a programme that will fit with the workplace demands of social care and focuses on issues that hold meaning and value to those we are seeking to engage. The work that we co-produce will therefore lead to tangible practice change and/or a strengthening of the evidence for existing practice. The University of Portsmouth (UoP) and Portsmouth City Council (PCC) do not currently have a research learning partnership established, however our civic partnership agreement provides a strong impetus to build a learning partnership that will inspire, engage, and provide professional development for social care professionals in research, whilst providing academics with direct experience of co-producing research in complex public service contexts. Through this project we aim to develop such a research learning partnership. Contributors: Amy Drahota, Reader in Health & Social Care Evidence & Evaluation, University of Portsmouth Carole Fogg, Senior Research Fellow, University of Southampton Patricia Gilbert, Lecturer (Sociology), University of Portsmouth Patryk Jadzinski, Senior Lecturer (Paramedics), University of Portsmouth Gail Mann, Research Development Lead, Portsmouth City Council Nils Niederstrasser, Senior Lecturer (Psychology), University of Portsmouth Lucy Porteous, Senior Lecturer (Social Work), University of Portsmouth Clare Rachwal, Deputy Head of Service, Adult Social Care, Portsmouth City Council Jenny Roddis, Associate Head (Research & Innovation), University of Portsmouth Sharon Smith, Principal Social Worker, Adult Social Care, Portsmouth City Council Annabel Tremlett, Senior Lecturer (Social Work), University of Portsmouth Aims and Objectives Our overall aim is to build research capacity in social care through establishing a research learning partnership between the University of Portsmouth (UoP) and Portsmouth City Council (PCC) adult social care team, the public and other key partners, and develop co-produced research relevant to PCC social care practice and national issues. We will achieve this via the following four objectives: A. To establish a research learning partnership for social care between UoP and PCC which will provide learning opportunities for both partners and their associated stakeholders around the development, design, and delivery of research. B. To identify and prioritise research topics for development for further grant funding opportunities, within social care and also in collaboration with other health and care delivery partners. C. To undertake preliminary research activities (e.g. a systematic review, public involvement activities, and potential data gathering) on a prioritised topic in adult social care, which will underpin a funding application for further primary research. D. To develop guidance on increasing capacity in social care research via co-production in collaboration with wider ARC Wessex social care research partnerships. Research Plan / Methods We will begin this project with a three-month exploratory process with social care teams, that will be about relationship-building and working together to devise a programme of activities that will meet the needs of social care, establish what a learning partnership would look like, and how this will fit with the expertise of academics. We envisage that we will co-develop some activities that centre around relevant topic(s) of importance to social care, and that the academics can support based on their expertise. Our focus will be adult social care, to tie in with the School of Health & Care Professions’ thematic strength in older adults, PCC’s adult social care team, and the ‘ageing and dementia’ research area of ARC Wessex. The project will involve a researcher-in-residence, employed by UoP but embedded within PCC, to work alongside adult social workers and build a culture of joint research across the organisations. We will be seeking to integrate research into current processes, for example through senior social worker team meetings and practice support forums that would be happening anyway. Throughout the project we will be seeking to establish a legacy of ongoing work and practice, through the development of funding applications for future projects and the development of a community of practice that will outlive the duration of the funding, nurture an affinity for research, and help demonstrate the value of research to social care. Summary of findings This project had four strands: 1: Growing a research culture and working together We helped six people at Portsmouth City Council (PCC) to become research active or develop their research skills; four were awarded ‘Visiting Researcher’ status at the university, and two were social workers employed on the joint social work project as research assistants. Of the four visiting researchers: One social worker received mentorship to undertake their own small research project; One Mental Health Practitioner developed their research ideas, and applied for research funding; Two individuals independently completed a research project and were supported to develop their analysis and findings through collaboration with University researchers. All individuals are pursuing further research and supporting each other. 2: Joint social work project A research question was developed through discussions and shadowing within adult social work teams at PCC. This led to a review of the evidence on how and why different features of collaborative working may impact the outcomes of older adults receiving services. We found 28 relevant studies that helped develop three theories on collaborative working. The theories relate to: how multidisciplinary team meetings are managed; how staff can learn from each other and feel safe to speak out; how new solutions for older adults can arise when staff feel safe to speak out. These theories can be used to develop recommendations and new interventions to improve how social workers can work with other professionals to provide the best care for older adults. 3: Research learning programme A 6-part seminar series, Research Skills in Social Care , was delivered in-person for colleagues at PCC and online for wider audiences. The series gave an overview of the six stages of conducting a literature review to grow research knowledge and encourage discussions. Team members also gave seminars on their research projects through the Applied Research Collaboration Wessex online seminar series. 4: Reflecting on what we have learnt about growing research The process of growing research has been rewarding and challenging. Success has come from mentorship and individual relationships where trust and rapport are developed, and confidence is built at a steady pace. Arranging rooms and technology in a different organisation for the seminar series was difficult, however the in-person nature of the seminars was beneficial for sparking informal conversations and removing barriers between research and practice, presenting an “accessible” face. What we did with this Knowledge The knowledge from the joint research project is being shared with the wider adult social work team to inform team development. Additionally, we are working the Health Determinants Research Collaboration (HDRC) at Portsmouth City Council to establish how the activities to grow research can be expanded to other areas of the city council and local authorities wider afield. We are working together to develop a report for publication and continue to work with the adult social work team to grow research. Where next? • A funding application has been submitted by an Approved Mental Health Professional to conduct a literature review around racial disparities in coercive mental health treatment •A social worker is planning small research project evidencing the need for a larger autism/neurodivergence support service for adults •Further collaboration with Health Determinants Research Collaboration initiative •Discussing development of interventions based on the findings of the joint research project. This will form the basis of a future funding proposal. Koren Luddington – Visiting Researcher & Social Worker “I was matched with a mentor from the University, who was empathic and reassuring of my self-doubts. She made me feel as though all questions were valid and she was able to provide explanations that felt personalised and relevant to my field of work” Taken from Koren’s blog post on NIHR ARC Wessex Supporting capacity building in this project has been really eye opening - throughout this project I have met incredible, passionate people that are doing everything they can to provide support. There is such a wealth of knowledge and innovation happening in Adult Social Care, and it’s up to us in research to support and encourage that. Dr Leah Fullegar Leah.Fullegar@port.ac.uk

eda5a835-7cd7-4129-9513-a5eae9f5b7ce ADOPTED: An observational longitudinal cohort study to investigate Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer’s disease (CONGA) Principal Investigator: Professor Chris Kipps Team: Steven Chance, Oxford Brain Diagnostics Ltd Robyn Davies, Cardiff and Vale University LHB Gail Hayward, University of Oxford, Nuffield Department of Primary Care Health Sciences, Margaret Glogowska, University of Oxford, Nuffield Department of Primary Care Health Sciences Jane Wolstenholme, University of Oxford, Health Economics Research Centre Filipa Landeiro, University of Oxford, Health Economics Research Centre Angus Prosser, University of Southampton Main Funding: NIHR i4i Starts: 6 March 2022 Ends: 31 June 2025 Summary Dementia is an umbrella term for a group of neurodegenerative diseases that cause cognitive and/or behavioural impairment that affect an individual’s function and daily living. Alzheimer’s disease (AD) is the most common dementia subtype, accounting for 60-70% of cases, followed by vascular dementia, mixed dementia, dementia with Lewy bodies, and frontotemporal dementia. Timely and accurate diagnosis of dementia is essential for appropriate care planning and signposting to sources of support. Early diagnosis and implementation of carer and patient interventions has been shown to improve patient and carer outcomes including health-related quality of life (HR-QoL) and delayed patient institutionalisation. With the promise of new therapeutic targets that may slow the progression of Alzheimer’s disease with early and targeted intervention, accurate and timely diagnosis is critical. Diagnosis is however challenging. Difficult cases can leave patients with uncertain diagnoses for long periods of time, where a “wait and see” approach is often employed when diagnostic tests are inconclusive. This can cause significant stress to both individuals living with cognitive impairment or dementia and their families. Definite dementia subtype diagnosis can currently only be obtained through post-mortem histopathological confirmation. Participants will be recruited through secondary and tertiary centres where diagnostic investigation or patient monitoring is underway. Participants will be followed for two years at 6 monthly intervals to determine change on standard cognitive and functional measures and collection of participant and companion reported health and social care events, with MRI examination at baseline and 24 months.

Other resources The ARC Wessex Implementation Team have developed a process to assess the implementation factors of ARC projects outputs. Our Implementation Checklist assesses how far research teams have considered implementation and enables us to determine the level of input we need to provide to support the implementation process. The checklist comprises six domains representing key elements in the process leading to implementation. Within each domain there are a set of statements addressing different aspects of this process and the conditions required for implementation. In addition, there are several questions which are intended as prompts to help make the assessment. To complete the checklist, think about your project and consider each statement within the domain and its accompanying question(s). Decide if you agree or disagree with the statement by placing a tick in the relevant column. You should also think about the evidence you have to support your response and details of this should be provided in the last column. If you have questions about the checklist email, please send these to arcwessex@soton.ac.uk addressed to the “Implementation Team” Complete the evaluation survey implementation checklist Implementation Checklist The ARC Wessex Implementation Team have developed a process to assess the implementation factors of ARC projects outputs. Our Implementation Checklist assesses how far research teams have considered implementation and enables us to determine the level of input we need to provide to support the implementation process. The checklist comprises six domains representing key elements in the process leading to implementation. Within each domain there are a set of statements addressing different aspects of this process and the conditions required for implementation. In addition, there are several questions which are intended as prompts to help make the assessment. To complete the checklist, think about your project and consider each statement within the domain and its accompanying question(s). Decide if you agree or disagree with the statement by placing a tick in the relevant column. You should also think about the evidence you have to support your response and details of this should be provided in the last column. If you have questions about the checklist email, please send these to arcwessex@soton.ac.uk addressed to the “Implementation Team” Download implementation checklist Learn more about implementation checklist Download implementation checklist Download the poster Introduction to Implementation - Dr David Kryl (video) Virtual workshop recorded in October 2020 (video) Use the Web-based Implementation Toolkit Video gallery Video gallery Implementation resources Bitesize guides to Implementation Bitesize guides to Implementation Play Video Play Video 10:12 Implementation Bitesize session 1- Dr David Kryl Implementation bitesize 1 - An introduction to Implementation by Dr David Kryl (10 minutes) Play Video Play Video 15:29 Implementation presentation Session 2 Dr Michelle Myall Implementation bitesize 2 - Implementation Science and Frameworks by Dr Michelle Myall Play Video Play Video 09:51 Implementation bitesize 3 - Checklist by Cindy Brooks Implementation bitesize 3 - Checklist by Cindy Brooks (10 minutes) Play Video Play Video 13:48 Implementation Bite size 4 Q & A.mp4 The ARC Wessex Implementation team answers your questions Implementation Checklist Play Video Play Video 10:54 Introduction to Implementation - Dr David Kryl Introduction to Implementation - Dr David Kryl (video) Play Video Play Video 01:15:22 Virtual workshop recorded in October 2020 Virtual workshop recorded in October 2020 (video) Summer Series 2021 Summer series 2021 Play Video Play Video 19:54 Summer Series Session 1: Study Outputs, Buy in & Engagement Cindy Brooks and Dr Michelle Myall explain Implementation in a series of summer sessions Live Q & A session Thursday 7th October 12.00pm Play Video Play Video 15:31 Summer Series Session 2: Fit and alignment with health and social care systems & priorities Summer Series Session 2: Fit and alignment with health and social care systems & priorities by Dr Michelle Myall and Cindy Brooks Play Video Play Video 11:12 Summer Series Session 3: Outcomes and Impact and Adoption and Spread Cindy Brooks and Dr Michelle Myall explain Implementation in a series of summer sessions Live Q & A session Thursday 7th October 12.00pm

Senior Research Fellow < Back Miguel Garcia-Argibay Senior Research Fellow Healthy Communities Coming soon Previous Next

3020cd35-d002-4b24-bc53-5ac051771722 Adopted Project: Paramedic delivery of end-of-life care: a mixed methods evaluation of service provision and professional practice (PARAID) Chief Investigator: Dr Natasha Campling, University of Southampton Funder: Marie Curie Research Grants Scheme Start Date: 1st March 2023 End Date: 7th October 2025 Partners: Research & Development Department, South East Coast Ambulance Service, University of the West of England, University of Southampton Summary Paramedics are often important to patients in the last year of their life (end-of-life). We know that 999 calls are increasing for individuals and their families at end-of-life, which may be because services in the community are under pressure e.g. those provided by family doctors and community nurses. Little wide scale research has been carried out to understand the contribution played by paramedics in these situations and how this might be improved. From practice it is known that paramedics attending patients at end-of-life face complex issues such as: not knowing the patient or their family, lack of availability of patient history, fear of doing wrong, issues with family conflict and a lack of healthcare professionals to hand over to out-of-hours if the patient is to remain at home. These issues can mean people are admitted to hospital when circumstances mean they could be cared for at home. The purpose of the study is to evaluate services and care provided by paramedics to people in the last year of life. We will survey paramedics throughout England to understand their professional practice and what factors influence this and conduct in-depth case studies (collecting information from patients, carers and healthcare professionals) to examine different ways of delivering services and how these shape paramedic decision-making and management of risk. It is important to evaluate service delivery and understand how the best service features can be incorporated into other services to improve the quality of care and support provided to patients and their families. This may prevent unnecessary hospital admissions at end-of-life, which often leads to people dying in hospital when most people state they would prefer to be cared for, and die, at home. The research will describe, characterise and evaluate paramedic delivered end-of-life service provision to answer the research question: how do different models of service provision shape paramedic practice and influence experiences and outcomes for individuals at end-of-life? The evaluation will enable service delivery models, their features, and effective risk management by paramedics to be distinguished to facilitate sharing of best practice and improve the quality of care and support for people at end-of-life.

c1df1831-b7ba-4277-88cf-bcbed05e91b7 Pharmacological And Non-Pharmacological treatment of ADHD in Pre-schoolers: a systematic review and network meta-analysis: the PANPAP study Lead applicant: Professor Samuele Cortese Co-applicants: Andrea Cipriani, Corentin Gosling, Luis Farhat, Cinzia Del Giovane Background: Children with Attention-Deficit/Hyperactivity Disorder (ADHD) have problems with attention and need to move more than most children. About 5% of school-aged children and 2% of pre-schoolers have ADHD, respectively. This translates into almost 10,000 pre-schoolers with ADHD in the South West England area. Interventions for ADHD include pharmacological and non-pharmacological treatments. When not treated, ADHD entails a significant burden to society, estimated at more than £20,000 per year. Therefore, it is important to detect and treat ADHD in the early years to prevent the negative consequences of ADHD later in life. Experts and ADHD support groups agree that the NHS does not meet the needs of pre-schoolers with ADHD. Currently, there are either long waiting lists or no services for pre-schoolers with ADHD in the NHS. To provide the best care for pre-schoolers with ADHD, we need to make sure that the NHS offers treatments that work well and are safe. In 2018, the National Institute for Health and Care Excellence (NICE) recommended mainly non-pharmacological interventions (behavioral interventions) for the treatment of pre-schoolers with ADHD. Back then, there was a paucity of studies on other non-pharamcological interventions and on medications for ADHD in pre-schoolers. Since 2018, there has been an increasing number of studies on other types of interventions (e.g., family-based interventions and diet) and on medications. There has also been an increasing trend in some countries (e.g., USA) to use medications for pre-schoolers with ADHD. Therefore, we need to understand which is the best intervention for pre-schoolers with ADHD. Aim: To compare the efficacy and safety of pharmacological and non-pharmacological interventions for ADHD in pre-schoolers. Methods: We will not do a new study, which would be very expensive. Rather, we will use a new type of research, called “network meta-analysis”. This approach uses data from available studies to compare different types of treatments even when they have not been compared directly in the individual available studies. Therefore, we will first systematically search for published and unpublished studies of any pharmacological or non-pharmacological treatment for pre-schoolers with ADHD. We will then combine the information from these studies with a state-of-the-art statistical approach. We will finally assess the quality of the studies included in the analysis and the strength of the evidence that we will generate. We are well known experts in this type of research. The study will be conducted at the University of Southampton, in collaboration with international researchers, including a statistician with renowned expertise in this type of analysis. Impact: The findings of our research are expected to inform future regional, national and international guidelines on the treatment of ADHD in pre-schoolers. As such, our results will be disseminated to local commissioners and policy makers, NICE, and international guidelines groups such as the European ADHD Guidelines Group. We will also disseminate our findings to associations of families with children with ADHD in the Wessex area, at the national (for example, National Attention Deficit Disorder Information and Support Service, ADDISS), and international level (ADHD Europe).

be5aaf78-5349-4834-a57a-fcddffbfb962 COMPLETED: GOODNIGHT Covid-19 to care-home-based vulnerable individuals Novel corona virus (COVID-19) is a virus that has spread quickly around the world. Elderly people with other health problems have a high death rate from the infection. There are no treatments for COVID-19 so prevention of infection is very important. COVID-19 is thought to infect people via the nose and mouth. Current best practise to prevent infection focuses on good hand hygiene, the wearing of masks and by limiting social contact. However, elderly people in care homes have to come into contact with staff members who are looking after them. Hypertonic saline nasal irrigation and gargling (HSNIG) has been shown to reduce the viral load of coronaviruses and has potential to reduce Covid-19 transmission in a community setting. The objective of this trial is to assess the feasibility and acceptability of care home staff adopting this technique. This research has now been submitted for publication. If you would like to know more about this study please contact Dr Ryan Buchanan Co-Chief investigators Dr Thomas Daniels, Consultant Respiratory Physician, Honorary Senior Clinical Lecturer, University of Southampton Dr Ryan Buchanan, Academic Clinical Lecturer, Primary Care, Population Science and Medical Education, University of Southampton Partners: University Hospital Southampton NHS Foundation Trust, Southampton CTU & NIHR ARC Wessex Co-applicants Professor Julie Parkes, Professor of Public Health, University of Southampton Professor Helen Roberts, Professor of Medicine for Older People, University of Southampton Emeritus Professor Jeremy Wyatt – University of Southampton Dr Beth Stuart – Medical Statistician, Southampton Clinical Trials Unit Dr Kinda Ibrahim - Senior Research Fellow, Faculty of Medicine, University Hospital Southampton NHS Foundation Trust Dr Andrew Cook – Public Health Consultant, Fellow of Health Technology Assessment, University of Southampton See the training video for Care Home staff: Publications http://dx.doi.org/10.14283/jnhrs.2021.3